Content of mediators of innate immunity in the tears of patients with vascular and neurodegenerative manifestations of diabetic retinopathy

According to the results of recent studies, diabetic retinopathy can be considered not only as a vascular disease, but also neurodegenerative process. Study composition tear fluid is used assess state local immunity in development eye diseases. However, studies examining effect are few. The aim study determine levels IL-1β, IL-10, TGF-β3, MMP-7, TIMP-2, protein S100b, BDNF and NGF ofpatients with manifestations retinopathy. included 80 patients diagnosed type 2 diabetes which were divided into groups: 1 st group 40 who had no clinical signs on fundus; nd initial non-proliferative All those examined an optical coherent tomograph RTVue-100 (USA); volume focal losses retinal ganglion cells (FLV) was determined. An increase FLV above normative base device regarded OCT-sign neurodegeneration. OCT, participants first second groups additionally 4 subgroups: 1A — without changes fundus OCT neurodegeneration (n = 12); 1B presence 28); 2A DR 10); 2B 30). S100 b, BDNF, determined by enzyme-linked immunosorbent assay. Levels IL-1β IL-10 all subgroups comparable controls throughout study. TGF-β3 content (group 2) significantly (p 0.001) lower compared control 2. there significant difference > 0.05) between A B within groups. concentration MMP-7 than < 0.05). (1B 2B), deficiency this metalloproteinase more pronounced 0.0001). neuropeptides under NGF, did differ from subgroups.